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Keep track of Carefully (two)pentobarbital will reduce the level or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Powerful CYP3A4 inducers may perhaps minimize suvorexant efficacy; if amplified suvorexant dose essential, tend not to exceed twenty mg/daypentobarbital will lessen the extent or